It is possible to hard-override any other set hotkey through a constant in the wp-config.php file. This feature is included for easy of use in a local development environment. Be careful for use on production websites as it can cause confusion when unaware and local set hotkeys are not working as expected.
// SHIFT, CMD, ALT, CTRL are available, all other keys are bind to a number. // See https://keycode.info (32 = Space) define( 'KEYBOARD_ACTION_HOTKEY', 'CTRL+ALT+32' );